منابع مشابه
Op-brai160064 1723..1734
The most common form of autosomal recessive hereditary spastic paraplegia is caused by mutations in the SPG11/KIAA1840 gene on chromosome 15q. The nature of the vast majority of SPG11 mutations found to date suggests a loss-of-function mechanism of the encoded protein, spatacsin. The SPG11 phenotype is, in most cases, characterized by a progressive spasticity with neuropathy, cognitive impairme...
متن کاملCaspar Friedrich Wolff (1734-1794)
Caspar Friedrich Wolff [4] is most famous for his 1759 doctoral dissertation, Theoria Generationis [5], in which he described embryonic development in both plants and animals as a process involving layers of cells, thereby refuting the accepted theory of preformation?the idea that organisms develop as a result of the unfolding of form that is somehow present from the outset, as in a homunculus....
متن کاملArctic ordeal. The journal of John Richardson, surgeonnaturalist with Franklin 1820–22
a trend towards small families, abortion, and homosexuality. With the outbreak of war, the Lebensborn's function was extended to the "germanization" of racially sound children from the occupied territories who were the offspring of liaisons between German military personnel and women from those territories or whose parents had been killed or imprisoned. Such children were effectively seized and...
متن کاملA Family of Early English Oculists (1600-1751), With a Reappraisal of John Thomas Woolhouse (1664-1733/1734)
INTRODUCTION John Thomas Woolhouse (1666-1733/1734), who practiced in Paris, was part of a family with 5 generations of English oculists. Some historians have derided him as a "charlatan" and have criticized him for adhering to the old notion that a cataract was a membrane anterior to the lens. METHODS We reviewed treatises and digital records related to Woolhouse and his family and the handw...
متن کاملDmd060244 1820..1825
Cytochrome P450 (P450) 2C9 is an important member of the P450 enzyme superfamily, with 58 CYP2C9 allelic variants previously reported. Genetic polymorphisms of CYP2C9 significantly influence the efficacy and safety of some drugs, which might cause adverse effects and therapeutic failure. The aim of this study was to assess the catalytic activities of 38 human CYP2C9 alleles, including 24 novel ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1970
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5728.171